Jennifer Jason Leigh – 58

Jennifer Jason Leigh made her screen debut with Eyes of a Stranger and the film turned out to be rather successful. She received Best Supporting Actress Awards for her work in a number of films, TV performances and stage appearances during her career, among other recognitions. She even has a dual-role performance under her belt in the Last Exit to Brooklyn. She has shared that her sister, who battles drug and alcohol addiction, is actually her inspiration.